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Interpretations of pre-collisional configurations of Greater India are highly controversial and predict distinct processes during the India-Asia collision. To better determine the possible pre-collisional configuration(s) of Greater India, we conduct a mass-balance analysis combined with previously published geologic, paleomagnetic, and geodynamic evidence. The mass-balance analysis determines the magnitude of northern Greater India (NGI) width needed to provide sufficient crustal accretion to form the Tethyan-Greater Himalaya orogenic wedge in Cenozoic time. Applying endmember crustal thicknesses of 10–40 km to a mass-balance equation yields a broad range of plausible pre-collisional NGI widths of ∼3016±1000 km and ∼956±283 km, respectively, which we further assess considering contrasting models/evidence. The integrated evidence requires a thin NGI continental crust to form 1) continuous Tethyan-Greater Himalayan crustal thickening, 2) a narrow foredeep width of Himalayan foreland basin, 3) continuous Gangdese arc magmatism with oceanic-subduction-style mantle wedge, and 4) low-magnitude exhumation in the North Himalaya and Gangdese arc-forearc from ∼60-30 Ma. Adding the structurally restored ∼740 km wide southern Greater India, the synthesized analyses yield two possible configurations: 1) an ∼1350±440 km wide and ∼23-30 km thick NGI indicating an ∼2080±450 km wide Greater India with ∼500-1000 km wide oceanic basin systems in both Asia and NGI; and 2) a ≥1815±630 km wide and ∼10-23 km thick Zealandia-type NGI indicating a ≥2550±640 km wide pre-collisional Greater India without or with limited ∼500-1000 km Xigaze back-arc oceanic basin. The former is conditionally consistent with the integrated evidence by assuming no Cenozoic oceanic subduction initiation within NGI and predicts multi-stage collision since ∼60 Ma. The latter is consistent with the integrated evidence and predicts an approximate-single-stage collision at ∼60 Ma. Both configurations predict significant post-collisional NGI crustal shortening that may have been accommodated by the Eocene-Oligocene Greater Himalayan structural discontinuities.